Little River Falls is located partway between Ft. Payne, AL and Gaylesville, AL. on US Hwy 35.
Turn onto Hwy 176 near the bridge at the falls and follow the signs. At one point you have a choice to make at a stop sign. You can either go straight and come out at Dogtown or make a left and come out on Hwy 273. If you make the left, then at Hwy 273 make a right and you will come out at Leesburg. Nice views and curves. Fun to ride and very isolated.
Do be careful though as at one point on the road there is a large boulder in the middle of the road where the lanes split and go on either side of the boulder.