Here's a great little detour if you're heading to Santa Fe or Taos from the east.
Follow this alternate route eastbound to connect to US-412 or bail off US-412 here if you're westbound. It's a great ride through open ranchland and the Kiowa National Grasslands.
Highlight is the twisty bit through the Canadian River canyon. Allow time to stop at this beautiful spot to take in the scenery.